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Synthesis and Bioactivity of Sol–Gel Derived Porous, Bioactive Glass Microspheres Using Chitosan as Novel Biomolecular Template
Author(s) -
Lei Bo,
Shin KwanHa,
Moon YoungWook,
Noh DaYoung,
Koh YoungHag,
Jin Yonghao,
Kim HyounEe
Publication year - 2012
Publication title -
journal of the american ceramic society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 196
eISSN - 1551-2916
pISSN - 0002-7820
DOI - 10.1111/j.1551-2916.2011.04918.x
Subject(s) - chitosan , porosity , materials science , apatite , microsphere , chemical engineering , precipitation , sol gel , bioactive glass , polymer , composite number , glass microsphere , simulated body fluid , nanotechnology , composite material , physics , meteorology , engineering
This article reports a novel, simple route for synthesis of sol–gel derived porous, bioactive glass ( BG ) microspheres using chitosan ( CTS ) as a biomolecular template in the acid‐catalyzed sol–gel process. The use of CTS , which is a natural biocompatible polymer with a unique molecular structure, allowed the synthesis of BG microparticles with a spherical shape, 5–10 μm in size. Furthermore, pores with a size of 5–40 nm were created entirely throughout BG microspheres, which were formed by removing the network of CTS present initially in the CTS‐BG composite microparticles via heat‐treatment at 600°C for 2 h. These porous BG microspheres induced the vigorous precipitation of apatite crystals on their surface when immersed in simulated body fluid for 24 h, thus suggesting their excellent bioactivity .