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Effect of Disordered Structure of Boron‐Containing Calcium Phosphates on their In Vitro Biodegradability
Author(s) -
Barheine Sabrina,
Hayakawa Satoshi,
Jäger Christian,
Shirosaki Yuki,
Osaka Akiyoshi
Publication year - 2011
Publication title -
journal of the american ceramic society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 196
eISSN - 1551-2916
pISSN - 0002-7820
DOI - 10.1111/j.1551-2916.2011.04400.x
Subject(s) - boron , biodegradation , apatite , chemical engineering , materials science , calcium , phosphate , nuclear chemistry , chemistry , mineralogy , organic chemistry , metallurgy , engineering
This study proposes a new guideline for designing biodegradable apatite ceramics. Boron‐containing hydroxyapatite (BHAp) particles were prepared by a high‐temperature solid‐state reaction processing method and were characterized in terms of their chemical composition, apatite lattice defects and in vitro biodegradability. Solid‐state nuclear magnetic resonance analysis showed that boron‐incorporation into hydroxyapatite (HAp) derived by thermo‐chemical reactions between borate and calcium phosphate phases led to disordered phases (BCaP) of a CaO–P 2 O 5 –B 2 O 3 –OH system covering the crystalline HAp core. X‐ray diffraction analysis indicated that the BCaP phase must consist mainly of a crystalline oxyboroapatite (OBAp) phase. An in vitro biodegradability test showed that BHAp degraded quicker than HAp or β‐tricalcium phosphate. The biodegradability of BHAp particles can be controlled by boron incorporation into a HAp lattice leading to the formation of a disordered OBAp phase.