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Effect of the HA/β‐TCP Ratio on the Biological Performance of Calcium Phosphate Ceramic Coatings Fabricated by a Room‐Temperature Powder Spray in Vacuum
Author(s) -
Hahn ByungDong,
Park DongSoo,
Choi JongJin,
Ryu Jungho,
Yoon WoonHa,
Lee ByoungKuk,
Kim HyounEe
Publication year - 2009
Publication title -
journal of the american ceramic society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 196
eISSN - 1551-2916
pISSN - 0002-7820
DOI - 10.1111/j.1551-2916.2009.02949.x
Subject(s) - dissolution , materials science , coating , microstructure , calcium , ceramic , phosphate , chemical engineering , titanium , composite material , metallurgy , chemistry , organic chemistry , engineering
Four calcium phosphate ceramic coatings, the less soluble hydroxyapatite (HA) coating, the more soluble β‐tricalcium phosphate (β‐TCP) coating, and two biphasic calcium phosphate (BCP) coatings with HA/β‐TCP ratios of 70/30 and 30/70 were fabricated by spraying each corresponding powder onto a titanium substrate at room temperature (RT) in a vacuum, in order to investigate the effect of the HA/β‐TCP ratio on the dissolution behavior and the cellular responses of the coating. No secondary phases, except for HA and β‐TCP, were observed for the coatings in the X‐ray diffraction results. The coating compositions were almost the same as those of the starting powders because the coating was conducted at RT. Microscopic examination of the coatings revealed crack‐free and dense microstructures. The BCP coatings exhibited dissolution rates intermediate between those of the pure HA and β‐TCP coatings. The dissolution rate of the coatings was largely dependent on their HA/β‐TCP ratio. The cell proliferation and differentiation results indicated that the cellular responses of the coatings were not proportional to their dissolution rates. The 3HA–7TCP (HA/β‐TCP ratio of 30/70) coating exhibited an optimal dissolution rate for excellent biological performance.