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Porous Hydroxyapatite Scaffolds Coated With Bioactive Apatite–Wollastonite Glass–Ceramics
Author(s) -
Jun InKook,
Song JuHa,
Choi WonYoung,
Koh YoungHag,
Kim HyounEe,
Kim HaeWon
Publication year - 2007
Publication title -
journal of the american ceramic society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 196
eISSN - 1551-2916
pISSN - 0002-7820
DOI - 10.1111/j.1551-2916.2007.01762.x
Subject(s) - bioactive glass , wollastonite , apatite , simulated body fluid , materials science , porosity , coating , scaffold , composite material , chemical engineering , ceramic , chemistry , biomedical engineering , scanning electron microscope , raw material , medicine , organic chemistry , engineering
The objective of this study was to fabricate porous hydroxyapatite (HA) scaffolds coated with bioactive A/W glass–ceramics and to examine their mechanical and biological properties. Firstly, the HA scaffolds were prepared by the polymeric sponge replication method, and then A/W glasses were coated on the surface of the struts. All of the scaffolds had a highly porous structure with well‐interconnected pores. It was observed that the bioactive glass coating markedly increased the strength of the HA scaffolds. This enhancement was attributed to the formation of a dense and strong coating layer on the weak HA struts. The in vitro bioactivities of the scaffolds were markedly improved by the coatings. When the coated scaffolds were soaked in a simulated body fluid (SBF), the bone‐like apatite crystals were well mineralized on their surfaces. Osteoblast‐like cells (MC3T3) adhered, spread, and grew well on the porous scaffolds. The cells placed on the glass‐coated HA scaffold showed a higher proliferation rate and alkaline phosphatase (ALP) activity than those on the pure HA scaffold. These results demonstrate that the bioactive glass coating is effective in improving the strength and bioactivity of the porous HA scaffolds.