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In Vitro Mineralization of Silicon Containing Calcium Phosphate Bioceramics
Author(s) -
Dorozhkin Sergey V.
Publication year - 2007
Publication title -
journal of the american ceramic society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 196
eISSN - 1551-2916
pISSN - 0002-7820
DOI - 10.1111/j.1551-2916.2006.01368.x
Subject(s) - mineralization (soil science) , simulated body fluid , aqueous solution , calcium , fumed silica , phosphate , silicon , chemical engineering , chemistry , nuclear chemistry , materials science , mineralogy , inorganic chemistry , apatite , organic chemistry , nitrogen , engineering
In vitro mineralization of silicon containing calcium phosphate (Si‐CaP) bioceramics was investigated in the constant‐composition double‐diffusion (CCDD) device under physiological conditions. The experiments were performed with porous pellets made of Si‐CaP, which was synthesized from Ca(NO 3 ) 2 ·4H 2 O, NH 4 H 2 PO 4 , ammonia and fumed silica according to a newly developed single‐stage preparation route. Twice as condensed aqueous solutions of the Kokubo's revised simulated body fluid (rSBF) were used as mineralizing medium. All samples of Si‐CaP bioceramics possessed excellent in vitro mineralizing properties and, therefore, this material is ready for further trials with cells. Simultaneously, the workability of the CCDD device in a less condensed (twofold instead of the previously used fourfold) aqueous solutions of rSBF was confirmed.