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Biocompatibility of Fluor‐Hydroxyapatite Bioceramics
Author(s) -
Lee EunJung,
Kim HaeWon,
Kim HyounEe
Publication year - 2005
Publication title -
journal of the american ceramic society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 196
eISSN - 1551-2916
pISSN - 0002-7820
DOI - 10.1111/j.1551-2916.2004.00172.x
Subject(s) - biocompatibility , sintering , osteoblast , materials science , chemical engineering , viability assay , solid state , chemistry , mineralogy , nuclear chemistry , cell , composite material , metallurgy , in vitro , biochemistry , engineering
Fluoridated hydroxyapatite (FHA) powders were fabricated by a solid‐state reaction, and their dense bodies were obtained by sintering at 1350°C. The biological performance of FHAs was evaluated and compared with that of pure hydroxyapatite (HA). The fluoridation of FHAs was confirmed by the changes in their lattice parameters. Human osteoblast‐like cells attached and proliferated well on all of the FHAs, including pure FA. The proliferation and differentiation levels of the cells on FHAs were similar to those on pure HA. This finding suggests that the FHAs possess cell viability and activity comparable to pure HA, and thus are potentially applicable as hard tissue substitutes.