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Multilocus Genotyping of Pneumocystis jirovecii in Patients Developing Diverse Forms of Parasitism: Implication for a Wide Human Reservoir for the Fungus
Author(s) -
TOTET ANNE,
LATOUCHE SOPHIE,
DUWAT HYACINTHE,
MAGOIS ELINE,
LACUBE PHILIPPE,
PAUTARD JEANCLAUDE,
SCHMIT JEANLUC,
JOUNIEAUX VINCENT,
ROUX PATRICIA,
RACCURT CHRISTIAN,
NEVEZ GILLES
Publication year - 2003
Publication title -
journal of eukaryotic microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.067
H-Index - 77
eISSN - 1550-7408
pISSN - 1066-5234
DOI - 10.1111/j.1550-7408.2003.tb00679.x
Subject(s) - pneumocystis jirovecii , biology , genotyping , genotype , fungus , medical microbiology , pneumocystis carinii , pneumocystis pneumonia , pneumonia , dhps , microbiology and biotechnology , virology , immunology , genetics , human immunodeficiency virus (hiv) , medicine , gene , botany , malaria , plasmodium falciparum
.Pneumocystis jirovecii ITS and DHPS genotypes were identified in 3 patient groups developing diverse forms of P. jirovecii infections: 13 patients with Pneumocystis pneumonia, 8 patients merely colonized by the fungus, and 19 immunocompetent infants with bronchiolitis developing mild P. jirovecii infection. Common P. jirovecii genotypes were found in the 3 patient groups, suggesting that common sources of P. jirovecii were involved in the fungus acquisition, and that transmission cycles of P. jirovecii infections in these patient groups are not independent. Parasitized patients, whatever the form of parasitism they present, may he part of a common reservoir for P. jirovecii.