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In Vitro Leishmanicidal Activity of a Monoclonal Antibody mimicking a Yeast Killer Toxin
Author(s) -
SAVOIA DIANELLA,
AVANZINI CLAUDLO,
CONTI STEFANIA,
MAGLIANI VALTER,
FRAZZI RAFFAELE,
POLONELLI UCIANO
Publication year - 2002
Publication title -
journal of eukaryotic microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.067
H-Index - 77
eISSN - 1550-7408
pISSN - 1066-5234
DOI - 10.1111/j.1550-7408.2002.tb00377.x
Subject(s) - biology , monoclonal antibody , leishmania infantum , leishmania , microbiology and biotechnology , protozoa , in vitro , antibody , toxin , leishmaniasis , antimicrobial , isotype , virology , parasite hosting , immunology , visceral leishmaniasis , biochemistry , world wide web , computer science
. The microbicidal effect of a monoclonal antiidiotypic antibody, mimicking the activity of a yeast killer toxin, characterized by a wide antimicrobial spectrum, has been evaluated in vitro against two relevant species of protozoan parasites, Leishmania major and Leishmania infantum. The antiidiotypic antibody exerted a significant and dose‐dependent antileishmanial activity against parasite promastigotes in comparison to an irrelevant isotype‐matched monoclonal antibody. This is the first demonstration that an antibody, which had been already shown to be fungicidal and bactericidal, may also exert a direct microbicidal activity against protozoa.