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In Vitro Replication of Nosema algerae (Microsporidia), a Parasite of Anopheline Mosquitoes, in Human Cells above 36° C
Author(s) -
TRAMMER THOMAS,
CHIORALIA GABRIELA,
MAIER WALTER A.,
SEITZ HANNS M.
Publication year - 1999
Publication title -
journal of eukaryotic microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.067
H-Index - 77
eISSN - 1550-7408
pISSN - 1066-5234
DOI - 10.1111/j.1550-7408.1999.tb06062.x
Subject(s) - microsporidia , biology , nosema , microsporidiosis , parasite hosting , protozoa , ultrastructure , zoology , virology , microbiology and biotechnology , spore , anatomy , world wide web , computer science
Microsporidia form a large and ubiquitous group of obligately intracellular parasitic eukaryotes, increasingly recognized as pathogens in humans. Transmission of invertebrate microsporidia to mammals has been considered impossible because temperature seemed to be a limiting factor for development. Nosema algerae , a microsporidian of anopheline mosquitoes, was cultured in human muscle fibroblasts at temperatures of 31° C and 38° C. This is the first record of an invertebrate microsporidian developing in human cells at a temperature above 36° C. The ultrastructure of N. algerue growing in human muscle fibroblasts is similar to that of Bruchiola vesicularum , a microsporidian species previously described in the muscle of an AIDS patient.