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Hypervariability in Gene Copy Number for the Glucose Transporter Genes in Trypanosomes
Author(s) -
BARRETT MICHAEL P.,
BRINGAUD FREDERIC,
DOUA FELIX,
MELVILLE SARA E.,
BALTZ THEO
Publication year - 1996
Publication title -
journal of eukaryotic microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.067
H-Index - 77
eISSN - 1550-7408
pISSN - 1066-5234
DOI - 10.1111/j.1550-7408.1996.tb01400.x
Subject(s) - biology , trypanosoma brucei , gene , trypanosoma , genetics , trypanosoma evansi , genome , subgenus , copy number variation , virology , trypanosomiasis , genus , botany
The copy number of the gene encoding the carrier protein responsible for the uptake of glucose in bloodstream form Trypanosoma brucei (THT1) was investigated in the genome of 55 different members of the subgenus Trypanozoon. The gene is present in multiple copies in tandem arrays on two homologous chromosomes in these organisms, and copy number varies both intra‐ and interspecifically. Variability is also apparent in the number of genes encoding a second hexose transporter (THT2) which is the only isoform expressed in procyclic organisms. Multiple copies of THT2 are conserved in representatives of the non‐tsetse transmitted species, Trypanosoma evansi and Trypanosoma equiperdum.