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Analysis of Genetic Diversity at the arom Locus in Isolates of Pneumocystis carinii
Author(s) -
BANERJI SUNEALE,
LUGLI ELENA B.,
MILLER ROBERT F.,
WAKEFIELD ANN E.
Publication year - 1995
Publication title -
journal of eukaryotic microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.067
H-Index - 77
eISSN - 1550-7408
pISSN - 1066-5234
DOI - 10.1111/j.1550-7408.1995.tb01614.x
Subject(s) - biology , pneumocystis carinii , gene , protozoa , genetics , genetic diversity , genetic divergence , dna , locus (genetics) , sequence analysis , nucleic acid sequence , polymerase chain reaction , virology , microbiology and biotechnology , population , demography , human immunodeficiency virus (hiv) , sociology , pneumocystis jirovecii
. The DNA sequences of a portion of the 5‐enolpyruvyl shikimate phosphate synthase domain of the arom gene, encoding the pentafunctional AROM protein, were determined from isolates of Pneumocystis carinii from five mammalian host species (rat, human, ferret, rabbit and mouse). High levels of genetic divergence were found among P. carinii derived from different hosts species, 7–22% at the DNA sequence level, and 7–26% at the derived amino acid sequence level. Two separate and distinct sequences were isolated from infected ferret lungs. Low levels of divergence were seen in human‐derived organisms.