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Effects of Mesoionic Xanthine Analogs On Trypanosoma Musculi Development In Mice
Author(s) -
SEN DILIP K.,
MBAGWU GODWIN O.,
ADSON ANTHONY
Publication year - 1993
Publication title -
journal of eukaryotic microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.067
H-Index - 77
eISSN - 1550-7408
pISSN - 1066-5234
DOI - 10.1111/j.1550-7408.1993.tb04914.x
Subject(s) - parasitemia , mesoionic , biology , parasite hosting , trypanosoma , in vivo , trypanosomiasis , inoculation , trypanosoma brucei , pharmacology , virology , immunology , malaria , biochemistry , microbiology and biotechnology , chemistry , plasmodium falciparum , medicinal chemistry , world wide web , computer science , gene
. Two derivatives of the mesoionic thiazolo[3,2‐a]pyrimidine‐5,7‐diones 1 were prepared and examined for in vivo antiprotozoan activity to study structure‐activity relationships that might lead us to more active derivatives. Mesoionic compounds 1A and 1B were inoculated into Swiss Webster male mice with Trypanosoma musculi infection. the effects were measured by studying parasite populations during the course of patent period (days 9 through 15 post‐infection). The injection of 200 μg of compound 1A along with 5 times 10 4 trypanosomes affected the level of parasitemia at both the peak and during days 9 to 13 post infection. Experimental animals that received drug 1A prior to and after infection with T. musculi developed significantly lower parasitemia as compared to the control animals at the height of parasite populations (day 11 of observation). the group that received the drug simultaneously with trypanosome infection had significantly lower parasitemias on day 11 and 13 of infection compared to the controls.