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Analysis of a Surface Antigen of Pneumocystis carinii
Author(s) -
LINKE MICHAEL J.,
WALZER PETER D.
Publication year - 1989
Publication title -
the journal of protozoology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.067
H-Index - 77
eISSN - 1550-7408
pISSN - 0022-3921
DOI - 10.1111/j.1550-7408.1989.tb05833.x
Subject(s) - pneumocystis carinii , glycoprotein , antigen , organism , biology , biochemistry , biotin , microbiology and biotechnology , moiety , chemistry , virology , immunology , stereochemistry , genetics , human immunodeficiency virus (hiv) , pneumocystis jirovecii
The 115 kd band in polyacrylamide gels is a major antigen of Pneumocystis carinii. Data obtained from treatment with enyzmes, binding to lectins, and labelling the surface with biotin suggest that this moiety is a glycoprotein containing mannosyl/glucosyl and N‐acetylglucosamine residues, and that it is located on the cell wall of the organism. Other rat and human P. carinii antigens also are glycoproteins but differ in specific protein or carbohydrate residues or location on the organism.