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Dynamics of Pneumocystis carinii ‐Specific Immune Complexes in AIDS Patients with P. carinii Pneumonia
Author(s) -
PIFER LINDA L.
Publication year - 1989
Publication title -
the journal of protozoology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.067
H-Index - 77
eISSN - 1550-7408
pISSN - 0022-3921
DOI - 10.1111/j.1550-7408.1989.tb05825.x
Subject(s) - pneumocystis carinii , pneumonia , immune system , virology , immunology , serology , immunopathology , antigen , biology , epitope , antibody , microbiology and biotechnology , medicine , human immunodeficiency virus (hiv) , pneumocystis jirovecii
Pneumocystis carinii‐specific immune complexes were detected by immunoblot and enzyme‐linked immunosorbent assay (EUSA) in 53% of sera from Acquired Immunodeficiency Syndrome (AIDS) patients with P. carinii pneumonia (PCP). Resolution of glycoprotein antigenemia (50–55 kd = dominant species) appears to correlate with successful PCP drug therapy and recovery. An epitope map has been constructed from im‐munoblots of P. carinii hydrolysates and from human and murine serum containing P. carinii antigens.