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Evidence Supporting the Existence of a Host Cell Surface Receptor for Trypanosoma cruzi1
Author(s) -
KIERSZENBAUM FELIPE,
STILES BRAD
Publication year - 1985
Publication title -
the journal of protozoology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.067
H-Index - 77
eISSN - 1550-7408
pISSN - 0022-3921
DOI - 10.1111/j.1550-7408.1985.tb03070.x
Subject(s) - trypanosoma cruzi , host (biology) , myocyte , biology , cell , receptor , microbiology and biotechnology , cell membrane , biochemistry , parasite hosting , ecology , world wide web , computer science
Membrane fragments from trypomastigote forms of Trypanosoma cruzi inhibited the association of intact trypomas‐ tigotes with rat heart myoblasts whereas a similar preparation from non‐invasive epimastigotes did not. Furthermore, killed trypo‐ mastigotes bound to the host cell surface and prevented the attachment of living organisms. Conversely, the extent of association of killed parasites with the host cells was reduced by the presence of living flagellates. These results suggest the presence of a distinct structure(s) on the surface of rat heart myoblasts to which infective forms of T. cruzi can bind.