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Fine Structural Alterations in Trypanosoma rhodesiense Grown In Vitro, Treated with WR 163577 1
Author(s) -
BERMAN J. D.,
OKA M.,
AIKAWA M.
Publication year - 1984
Publication title -
the journal of protozoology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.067
H-Index - 77
eISSN - 1550-7408
pISSN - 0022-3921
DOI - 10.1111/j.1550-7408.1984.tb04315.x
Subject(s) - kinetoplast , cytoplasm , in vitro , chromatin , dna , trypanosoma , kinetoplastida , microbiology and biotechnology , biology , trypanosoma cruzi , chemistry , biochemistry , parasite hosting , virology , world wide web , computer science
Fine‐structural alterations in Trypanosoma rhodesiense trypomastigotes exposed to WR 163577, a prophylactic agent against animal African trypanosomiasis, were determined from cells grown in vitro. Exposure of trypomastigotes to a low concentration of drug resulted only in condensation of kinetoplast DNA fibrils. Exposure to higher drug concentrations caused clumping of nuclear chromatin and of cytoplasmic contents. Although alteration of kinetoplast DNA is the first detectable drug‐induced change, the function of the kinetoplast in mammalian forms of African trypanosomes is unclear, and the secondary changes in the nucleus and cytoplasm may constitute the functionally significant alterations caused by WR 163577.