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Effect of Gossypol upon Motility and Ultrastructure of Trypanosoma cruzi 1
Author(s) -
BLANCO ANTONIO,
AOKI AGUSTIN,
MONTAMAT ENRIQUE E.,
ROVAI LEONOR E.
Publication year - 1983
Publication title -
the journal of protozoology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.067
H-Index - 77
eISSN - 1550-7408
pISSN - 0022-3921
DOI - 10.1111/j.1550-7408.1983.tb05337.x
Subject(s) - gossypol , trypanosoma cruzi , ultrastructure , mitochondrion , incubation , kinetoplast , motility , trypanosoma brucei , chemistry , biochemistry , biology , microbiology and biotechnology , botany , dna , parasite hosting , gene , world wide web , computer science
Gossypol, a polyphenolic compound from the cotton plant, immobilizes and structurally alters cultured Trypanosoma cruzi epimastigotes. Ultrastructural changes observed in gossypol‐treated parasites were first detected in the kinetoplast and mitochondrion. At 50 μM concentration, much disorganization was evident after 5 min of incubation. With 25 μM gossypol, the same effect occurred after 30 min. Most epimastigotes were rounded, containing various membranous structures that could not be related to known cell components.