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In Vitro Response of Blastocystis hominis to Antiprotozoal Drugs
Author(s) -
ZIERDT CHARLES H.,
SWAN JUDITH C.,
HOSSEINI JEANETTE
Publication year - 1983
Publication title -
the journal of protozoology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.067
H-Index - 77
eISSN - 1550-7408
pISSN - 0022-3921
DOI - 10.1111/j.1550-7408.1983.tb02925.x
Subject(s) - blastocystis , metronidazole , antiprotozoal , nitazoxanide , paromomycin , microbiology and biotechnology , furazolidone , emetine , pharmacology , pentamidine , chloroquine , axenic , quinoline , diarrhea , in vitro , antibiotics , traditional medicine , biology , chemistry , medicine , immunology , feces , malaria , biochemistry , bacteria , pneumonia , genetics , aminoglycoside , organic chemistry
Ten antiprotozoal drugs were tested in vitro against four axenic strains of the intestinal parasite Blastocystis hominis. Inhibitory drugs in order of effectiveness were emetine, metronidazole, furazolidone, trimethoprim sulfamethoxazole, 5‐chloro‐8‐hydroxy‐7‐iodo‐quinoline (Entero‐Vioform), and pentamidine. Moderately inhibitory were two quinolines other than iodochlorhydroxquin. These were chloroquine and 5, 7‐diiodo‐8‐hydroxy‐quinoline(Floraquin). Diloxanide furoate was not inhibitory. Paromomycin and other antibiotics were not inhibitory. Entero‐Vioform and metronidazole have been effective in human and higher primate diarrhea caused by B. hominis .