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Regulation of Ribosomal RNA Transcription During Differentiation of Acanthamoeba castellanii : A Review
Author(s) -
PAULE MARVIN R.
Publication year - 1983
Publication title -
the journal of protozoology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.067
H-Index - 77
eISSN - 1550-7408
pISSN - 0022-3921
DOI - 10.1111/j.1550-7408.1983.tb02905.x
Subject(s) - rna polymerase ii , biology , transcription (linguistics) , general transcription factor , ribosomal rna , transcription factor ii d , rna polymerase ii holoenzyme , microbiology and biotechnology , rna polymerase , rna , genetics , gene expression , gene , promoter , linguistics , philosophy
During the cellular differentiation induced by starvation of Acanthamoeba castellanii , the expression of a number of genes is regulated. Evidence is reviewed that at least one of these, the precursor ribosomal RNA transcription unit, is regulated at the level of transcription. The structure of the rRNA transcription unit and of the RNA polymerases responsible for transcription in Acanthamoeba are reviewed. Utilizing an in vitro transcription system constructed from these components, preliminary evidence has been obtained that pre‐rRNA gene expression is regulated by a modification of RNA polymerase I that affects the enzyme's ability to participate efficiently in the initiation of transcription. These results are reviewed in relation to other known mechanisms of transcriptional regulation in eukaryotes.