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A Comparison of Growth Inhibition of Tetrahymena furgasoni by C 19 and C 21 Steroids
Author(s) -
LAMONTAGNE N. S.,
BROOKS J. M.,
JOHNSON D. F.
Publication year - 1982
Publication title -
the journal of protozoology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.067
H-Index - 77
eISSN - 1550-7408
pISSN - 0022-3921
DOI - 10.1111/j.1550-7408.1982.tb04019.x
Subject(s) - degree of unsaturation , tetrahymena pyriformis , chemistry , steroid , stereochemistry , tetrahymena , population , growth inhibition , transformation (genetics) , biochemistry , cell growth , organic chemistry , gene , demography , sociology , hormone
The growth inhibition of Tetrahymena furgasoni (once known as “ T. pyriformis W”) by C 19 and C 21 steroids of similar structure was measured by determining cell population at 24 h and 48 h following addition of the steroid. A cis‐fusion of the A/B rings junction, unsaturation at C‐1,2, or C‐4,5 and carbonyl substitution all enhanced inhibition, whereas the presence of two hydroxyl groups decreased inhibition. The results indicated that the transformation of C 19 and C 21 steroids by this protozoon may be part of a detoxication mechanism.