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Antigens of Subcellular Fractions of Trypanosoma cruzi. III. Humoral immune response and histopathology of immunized mice *
Author(s) -
CAPPA STELLA M. GONZALEZ,
BRONZINA ADRIANA,
KATZIN ALEJANDRO M.,
GOLFERA HUMBERTO,
MARTINI GLADYS W. DE,
SEGURA ELSA L.
Publication year - 1980
Publication title -
the journal of protozoology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.067
H-Index - 77
eISSN - 1550-7408
pISSN - 0022-3921
DOI - 10.1111/j.1550-7408.1980.tb05399.x
Subject(s) - trypanosoma cruzi , immune system , antigen , histopathology , humoral immunity , immunology , biology , virology , microbiology and biotechnology , parasite hosting , medicine , pathology , world wide web , computer science
SYNOPSIS. The relation of humoral antibody response to protection was evaluated in mice immunized with whole homogenates of Trypanosoma cruzi or with its flagellar fraction by direct agglutination and indirect fluorescent antibody test as well as by lytic and neutralizing activity against blood trypomastigotes. The results indicated that lytic antibodies were not implicated directly in protection against these trypanosomes. It was evident from histopathologic examination that the higher the degree of protection achieved, the lower the tissue damage observed in the challenged mice. Serum‐neutralizing activity was highest in the groups protected most effectively.