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Sporozoites of Mammalian Malaria: Attachment To, Interiorization and Fate Within Macrophages
Author(s) -
DANFORTH HARRY D.,
AIKAWAD̊ MASAMICHI,
COCHRANE ALAN H.,
NUSSENZWEIG RUTH S.
Publication year - 1980
Publication title -
the journal of protozoology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.067
H-Index - 77
eISSN - 1550-7408
pISSN - 0022-3921
DOI - 10.1111/j.1550-7408.1980.tb04680.x
Subject(s) - phagocytosis , biology , macrophage , plasmodium berghei , vacuole , intracellular parasite , antibody , parasite hosting , intracellular , microbiology and biotechnology , virology , immunology , malaria , in vitro , cytoplasm , biochemistry , world wide web , computer science
Sporozoites of Plasmodium berghei and Plasmodium knowlesi, incubated in normal serum readily interact with peritoneal macrophages of mice or rhesus monkeys, respectively. Interiorization of the sporozoite requires that both serum and macrophages be obtained from an animal susceptible to infection by the malaria parasite. Serum requirements for sporozoite attachment to the macrophage are less specific. Phagocytosis is not essential for the parasites to become intracellular. Our findings indicate that active penetration of the sporozoites into the macrophages does occur.