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Inhibition of Leishmania Donovani Amastigote‐To‐Promastigote Transformation By Infected Hamster Spleen Lymphocyte Lysates *
Author(s) -
KRASSNER STUART M.,
MORROW CASEY D.,
FLORY BARBARA
Publication year - 1980
Publication title -
the journal of protozoology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.067
H-Index - 77
eISSN - 1550-7408
pISSN - 0022-3921
DOI - 10.1111/j.1550-7408.1980.tb04233.x
Subject(s) - amastigote , leishmania donovani , spleen , hamster , transformation (genetics) , biology , leishmania , lymphocyte , in vitro , leishmaniasis , microbiology and biotechnology , immunology , visceral leishmaniasis , biochemistry , parasite hosting , world wide web , computer science , gene
SYNOPSIS Leishmania donovani amastigote‐to‐promastigote transformation is inhibited by homogenates of infected hamster liver and spleen. This inhibitory activity is localized in the 100,000 g pellet fraction. Tests with lysates of adherent (macrophyages) and nonadherent (lymphocytes) spleen cells indicated that the inhibitory activity resided in the lymphocytes, specifically in the 100,000 g pellet fraction.