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Growth of Leishmania donovani Amastigotes in a Continuous Macrophage‐Like Cell Culture*
Author(s) -
BERENS RANDOLPH L.,
MARR J. JOSEPH
Publication year - 1979
Publication title -
the journal of protozoology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.067
H-Index - 77
eISSN - 1550-7408
pISSN - 0022-3921
DOI - 10.1111/j.1550-7408.1979.tb04652.x
Subject(s) - amastigote , leishmania donovani , macrophage , leishmania , cell culture , intracellular , biology , microbiology and biotechnology , cell , leishmaniasis , immunology , in vitro , visceral leishmaniasis , genetics , parasite hosting , world wide web , computer science
SYNOPSIS. The feasibility of using a macrophage‐like murine tumor cell as a host for Leishmania donovani was investigated. This cell line, designated P388D 1 , rapidly phagocytized amastigotes and supported their intracellular replication. It can serve as a model “host” without the inherent limitations of primary macrophage cultures.