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Mechanism of Acquired Immunity Induced by “ Leptomonas pessoai ” against Trypanosoma cruzi in Mice *
Author(s) -
SOUZA MARIA DO CARMO,
REIS A. P.,
SILVA W. DIAS,
BRENER Z.
Publication year - 1974
Publication title -
the journal of protozoology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.067
H-Index - 77
eISSN - 1550-7408
pISSN - 0022-3921
DOI - 10.1111/j.1550-7408.1974.tb03705.x
Subject(s) - trypanosoma cruzi , complement fixation test , biology , antibody , immunity , antigen , immune system , virology , immunodiffusion , immunology , microbiology and biotechnology , immune adherence , hemagglutination , chagas disease , parasite hosting , serology , world wide web , computer science
SYNOPSIS Living culture forms of “ Leptomonas pessoai ” cross protected mice against T. cruzi challenge infection. Circulating antibodies have been detected in the immunized mice by immunodiffusion analysis, passive hemagglutination, complement fixation test and antibody binding assay; these antibodies cross reacted with T. cruzi extracts. A cellular immune response was indicated by leucocyte migration inhibition using L. pessoai and T. cruzi antigens, strongly suggesting a role for cell‐mediated immunity in the mechanism of protection induced by L. pessoai.