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Some Qualitative Aspects of Spleen Cell Transfer Studies on Plasmodium berghei ‐Infected Rats *
Author(s) -
CABRERA EDELBERTO J.,
ALGER NELDA E.,
SILVERMAN PAUL H.
Publication year - 1973
Publication title -
the journal of protozoology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.067
H-Index - 77
eISSN - 1550-7408
pISSN - 0022-3921
DOI - 10.1111/j.1550-7408.1973.tb00922.x
Subject(s) - plasmodium berghei , spleen , adoptive cell transfer , parasitemia , immunity , syngenic , biology , immunology , plasmodium (life cycle) , malaria , virology , immune system , parasite hosting , t cell , plasmodium falciparum , world wide web , computer science
SYNOPSIS. Adoptive immunity to Plasmodium berghei was transferred by intraperitoneal injections into rats, never before exposed to this parasite, of either 2 × 10 7 or 2 × 10 8 , but not of 2 × 10 6 , spleen cells from syngenic rats which had recovered from a primary P. berghei infection. When the spleen cells from the latter animals were kept at 47 C for 45 min they remained alive, but no longer were able to transfer protection. The capacity to transfer adoptive immunity was not found in spleen cells from adult rats capable of age immunity. On the other hand, this capacity was found in spleen cells from rats that had suffered a very transient parasitemia (> 1% peak parasitemia).