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Adoptive Transfer of Immunity to Plasmodium berghei by Spleen and Lymph Node Cells from Young and Old Mice *
Author(s) -
KASPER LLOYD H.,
ALGER NELDA E.
Publication year - 1973
Publication title -
the journal of protozoology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.067
H-Index - 77
eISSN - 1550-7408
pISSN - 0022-3921
DOI - 10.1111/j.1550-7408.1973.tb00921.x
Subject(s) - spleen , plasmodium berghei , lymph node , adoptive cell transfer , immunity , immune system , lymph , immunology , biology , malaria , medicine , pathology , t cell
SYNOPSIS. Different numbers of spleen and lymph node cells of 6‐week and 6–8 month A/J mice, immune to Plasmodium berghei , were transferred into normal 4‐week old mice. Better protection was observed with 2.5 × 10 s than with 10 7 spleen cells, and spleen cells afforded better protection than an equal number of lymph node cells. Further, spleen cells from older mice were more effective than those from young animals. Possible mechanisms of immunity transfer are discussed.