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Plasmodium berghei NK65 in the Inbred A/J Mouse: Age Immunity in the Female Retired Breeder A/J Mouse *
Author(s) -
ALGER NELDA E.,
BRANTON MARILYN,
HARANT JOYCE,
WILLIS LINDA,
SILVERMAN PAUL H.
Publication year - 1972
Publication title -
the journal of protozoology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.067
H-Index - 77
eISSN - 1550-7408
pISSN - 0022-3921
DOI - 10.1111/j.1550-7408.1972.tb03516.x
Subject(s) - plasmodium berghei , virulence , breeder (animal) , biology , immunity , population , inbred strain , virology , immunology , immune system , medicine , malaria , genetics , gene , history , environmental health , archaeology , blanket
SYNOPSIS. Death rates of A/J and CF 1 female mice 4 weeks and 6 months of age were compared after the mice were infected with Plasmodium berghei NK65C deme (population) and NK65RR deme. Death rates were compared also when female A/J retired breeder mice were infected with blood passages 18 and 40 of NK65C. NK65C was found to be less virulent than NK65RR. The 40th blood passage of NK65C was more virulent than the 18th passage, but still not as virulent at the NK65RR deme. A/J retired breeders were clearly more resistant to infection than 4 week old A/J mice, while little difference was found in the different age groups of the CF 1 mice.