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Ethionine and Methionine Metabolism by the Chrysomonad Flagellate Ochromonas danica
Author(s) -
HOCHBERG A.,
RAHAT M.
Publication year - 1971
Publication title -
the journal of protozoology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.067
H-Index - 77
eISSN - 1550-7408
pISSN - 0022-3921
DOI - 10.1111/j.1550-7408.1971.tb03360.x
Subject(s) - ethionine , methionine , cysteine , biochemistry , flagellate , methionine synthase , homocysteine , metabolism , chemistry , moiety , biology , stereochemistry , amino acid , enzyme , botany
SYNOPSIS. Growth of Ochromonas danica is competitively inhibited by ethionine. Inhibition can be reversed by methionine. Inhibition indexes of the effect of ethionine on growth and methionine incorporation into proteins are 1 and 4, respectively. Inside the cell, methionine is partially de‐methylated and metabolized to form cysteine. Ethionine is partially de‐ethylated, and the homocysteine moiety is either re‐methylated to form methionine or further metabolized to form cysteine. Ethionine is also incorporated into proteins of O. danica. The kind of metabolic interference, expressed by inhibition of growth, and correlated with incorporation of ethionine, is yet unknown.