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Incorporation of Precursors into Toxoplasma DNA
Author(s) -
PERROTTO JOSEPH,
KEISTER DAVID B.,
GELDERMAN ALBERT H.
Publication year - 1971
Publication title -
the journal of protozoology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.067
H-Index - 77
eISSN - 1550-7408
pISSN - 0022-3921
DOI - 10.1111/j.1550-7408.1971.tb03356.x
Subject(s) - obligate , orotic acid , dna , toxoplasma gondii , purine , dna synthesis , thymidine , pyrimidine , biochemistry , chemistry , intracellular parasite , purine metabolism , thymine , biology , intracellular , genetics , botany , enzyme , antibody
SYNOPSIS. DNA synthesis of Toxoplasma gondii differs from that of other obligate intracellular parasites in that the parasite can synthesize DNA independently of the host cell and can incorporate preformed pyrimidines as well as pyrimidine precursors. However, pyrimidine precursors such as orotic acid are preferentially utilized over preformed pyrimidines such as thymidine. There is little apparent utilization of purine precursors.