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Adoptive Transfer of Immunity to Plasmodium berghei
Author(s) -
ROBERTS J. A.,
TRACEYPATTE P.
Publication year - 1969
Publication title -
the journal of protozoology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.067
H-Index - 77
eISSN - 1550-7408
pISSN - 0022-3921
DOI - 10.1111/j.1550-7408.1969.tb02334.x
Subject(s) - plasmodium berghei , parasitemia , adoptive cell transfer , spleen , immunity , immune system , bone marrow , lymph node , immunology , biology , lymphatic system , lymph , thoracic duct , malaria , medicine , t cell , pathology , plasmodium falciparum
SYNOPSIS. Immunity to P. berghei in rats was transferred adoptively with spleen cells but not with bone marrow cells, thymus cells, peripheral lymph node cells or thoracic duct lymphocytes from immune donors. The parasite multiplies at the same rate in control and protected rats but when about 10% of host red cells are infected the number of infected cells in protected rats decreases rapidly whereas control rats attain high parasitemias and die. Serum from immune donors delays the onset of parasitemia but does not affect its ultimate course or the fate of the recipient.