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Effects of Immobilizing Antiserum and Normal Serum on Paramecium Surface Antigen Synthesis
Author(s) -
FINGER IRVING,
HELLER CAROL,
DILWORTH LINDA
Publication year - 1969
Publication title -
the journal of protozoology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.067
H-Index - 77
eISSN - 1550-7408
pISSN - 0022-3921
DOI - 10.1111/j.1550-7408.1969.tb02226.x
Subject(s) - antiserum , antigen , rabbit (cipher) , antibody , homologous chromosome , biology , ammonium sulfate , immune sera , transformation (genetics) , immunology , microbiology and biotechnology , chemistry , virology , biochemistry , chromatography , gene , statistics , mathematics
SYNOPSIS. Rabbit antiserum can transform paramecia from one scrotype to a 2nd antigenic type. Altho homologous antisera made against antigens sharing the same specificity as that of a treated cell are most effective, other sera lacking crossreacting antibodies also can induce transformation. Furthermore, normal serum from unimmunized animals will often have the same effect. A 0‐40% ammonium sulfate fraction of serum removes a lethal factor, leaving behind an efficient agent for transformation. The activily of this agent will vary from rabbit to rabbit, and apparently is characteristic of a particular rabbit.