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Factors Influencing the Infectivity of a Trypanosoma brucei Stabilate for Mice
Author(s) -
LUMSDEN W. H. R.,
GITATHA S. K.,
LUTZ W.
Publication year - 1968
Publication title -
the journal of protozoology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.067
H-Index - 77
eISSN - 1550-7408
pISSN - 0022-3921
DOI - 10.1111/j.1550-7408.1968.tb02096.x
Subject(s) - infectivity , inoculation , trypanosoma brucei , medicine , significant difference , virology , biology , immunology , biochemistry , virus , gene
SYNOPSIS. Mice, segregated in groups according to sex and age from 5 to 21 weeks, and randomly presented, were inoculated in one continuous process with a trypanosome suspension prepared from a Trypanosoma brucei subgroup stabilate of such a dilution that about 50% of the mice might be expected to become infected. No statistically significant difference occurred between groups, either with regard to sex or to age. Significant alterations in the proportions of mice infected did, however, occur in relation to inoculation order. The inoculation process occupied 12–197 minutes after removal of the stabilate from −79 C storage. Essentially, infectivity rose initially to a peak between 30 and 80 minutes, and then fell off, but was not abolished at the end of the experiment.