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Evaluation of Some Trypanostatic Agents by Means of Herpetomonas culicidarum
Author(s) -
GROSSOWICZ NATHAN,
RASOOLY GOORY
Publication year - 1958
Publication title -
the journal of protozoology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.067
H-Index - 77
eISSN - 1550-7408
pISSN - 0022-3921
DOI - 10.1111/j.1550-7408.1958.tb02562.x
Subject(s) - nystatin , pentamidine , microbiology and biotechnology , antibiotics , antifungal , flagellate , biology , chemistry , medicine , pneumonia , botany
SYNOPSIS. A rapid quantitative method for measuring trypanostatic activity by means of the nonpathogenic flagellate Herpetomonas culicidarum is described. Of the known trypanocidal agents tested, pentamidine was the most active; stilbamidine and propamidine somewhat less active. H. culicidarum is more resistant to these agents than are some pathogenic hemoflagellates. Two new antifungal antibiotics, nystatin and heptamycin (a candicidin‐like antibiotic), had powerful trypanostatic activity in vitro. The potential trypanostatic activity of antifungal agents is noted.