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Microvascular Dysfunction: A Potential Mechanism in the Pathogenesis of Obesity‐associated Insulin Resistance and Hypertension
Author(s) -
DE BOER MICHIEL P.,
MEIJER RICK I.,
WIJNSTOK NIENKE J.,
JONK AMY M.,
HOUBEN ALPHONS J.,
STEHOUWER COEN D.,
SMULDERS YVO M.,
ERINGA ETTO C.,
SERNÉ ERIK H.
Publication year - 2012
Publication title -
microcirculation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.793
H-Index - 83
eISSN - 1549-8719
pISSN - 1073-9688
DOI - 10.1111/j.1549-8719.2011.00130.x
Subject(s) - insulin resistance , adipose tissue , obesity , medicine , endothelial dysfunction , diabetes mellitus , pathogenesis , disease , mechanism (biology) , microcirculation , type 2 diabetes , insulin , bioinformatics , endocrinology , biology , philosophy , epistemology
Please cite this paper as: de Boer, Meijer, Wijnstok, Jonk, Houben, Stehouwer, Smulders, Eringa and Serné (2012). Microvascular Dysfunction: A Potential Mechanism in the Pathogenesis of Obesity‐associated Insulin Resistance and Hypertension. Microcirculation 19 (1), 5–18. Abstract The intertwined epidemics of obesity and related disorders such as hypertension, insulin resistance, type 2 diabetes, and subsequent cardiovascular disease pose a major public health challenge. To meet this challenge, we must understand the interplay between adipose tissue and the vasculature. Microvascular dysfunction is important not only in the development of obesity‐related target‐organ damage but also in the development of cardiovascular risk factors such as hypertension and insulin resistance. The present review examines the role of microvascular dysfunction as an explanation for the associations among obesity, hypertension, and impaired insulin‐mediated glucose disposal. We also discuss communicative pathways from adipose tissue to the microcirculation.