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17β‐Estradiol and Progesterone Independently Augment Cutaneous Thermal Hyperemia But Not Reactive Hyperemia
Author(s) -
BRUNT VIENNA E.,
MINER JENNIFER A.,
MEENDERING JESSICA R.,
KAPLAN PAUL F.,
MINSON CHRISTOPHER T.
Publication year - 2011
Publication title -
microcirculation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.793
H-Index - 83
eISSN - 1549-8719
pISSN - 1073-9688
DOI - 10.1111/j.1549-8719.2011.00095.x
Subject(s) - medicine , endocrinology , hormone , estrogen , reactive hyperemia , endogeny , blood flow , chemistry
Please cite this paper as: Brunt, Miner, Meendering, Kaplan, and Minson (2011). 17β‐Estradiol and Progesterone Independently Augment Cutaneous Thermal Hyperemia But Not Reactive Hyperemia. Microcirculation 18 (5), 347–355. Abstract Objective: We examined the impact of estradiol and progesterone on skin LH and RH in 25 healthy women. Methods: Subjects were studied three times over 10–12 days. Endogenous sex hormones were suppressed with a GnRHa. Subjects were studied on day 4 of suppression ( study day 1 ), three to four days later following treatment with either 17β‐estradiol or progesterone ( study day 2 ), and another three to four days later, following treatment with both estradiol and progesterone ( study day 3 ). Subjects underwent identical LH and RH protocols on all study days. LH is characterized by an initial peak in blood flow, followed by a prolonged plateau. A brief nadir is seen between the phases. Results: Blood flow values are expressed as percent maximum CVC. Estradiol alone increased initial peak CVC from 71 ± 2% to 79 ± 2% ( p = 0.001). Progesterone alone increased initial peak CVC from 72 ± 2% to 78 ± 2% ( p = 0.046). Neither estradiol nor progesterone increased plateau CVC. No significant changes were seen between study days 2 and 3 for either group. No differences were observed in RH. Conclusions: Both estradiol and progesterone increased initial peak CVC during LH, without altering plateau CVC. There was no additive effect of estradiol and progesterone.