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Orthopedic Trauma‐Induced Pulmonary Injury in the Obese Zucker Rat
Author(s) -
XIANG LUSHA,
HESTER ROBERT L.,
FULLER WILLIAM L.,
SEBAI MOHAMAD E.,
MITTWEDE PETER N.,
JONES ELIZABETH K.,
ANEJA ARUN,
RUSSELL GEORGE V.
Publication year - 2010
Publication title -
microcirculation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.793
H-Index - 83
eISSN - 1549-8719
pISSN - 1073-9688
DOI - 10.1111/j.1549-8719.2010.00061.x
Subject(s) - pulmonary edema , medicine , orthopedic surgery , vascular permeability , edema , lung , basal (medicine) , bronchoalveolar lavage , inflammation , prostaglandin e2 , endocrinology , anesthesia , surgery , insulin
Please cite this paper as: Xiang, Hester, Fuller, Sebai, Mittwede, Jones, Aneja and Russell (2010). Orthopedic Trauma‐Induced Pulmonary Injury in the Obese Zucker Rats. Microcirculation 17(8) , 650–659. Abstract Objective: Obese subjects with orthopedic trauma exhibit increased inflammation and an increased risk of pulmonary edema. Prostaglandin E 2 (PGE 2 ) production is elevated during inflammation and associated with increased vascular permeability. We hypothesize that pulmonary edema in obesity following orthopedic trauma is due to elevated PGE 2 and resultant increases in pulmonary permeability. Methods: Orthopedic trauma was induced in both hindlimbs in lean (LZ) and obese Zucker rats (OZ). On the following day, plasma interleukin‐6 (IL‐6) and PGE 2 levels, pulmonary edema, and pulmonary gas exchange capability were compared between groups: LZ, OZ, LZ with trauma (LZT), and OZ with trauma (OZT). Vascular permeability in isolated lungs was measured in LZ and OZ before and after application of PGE 2 . Results: As compared with the other groups, the OZT exhibited elevated plasma IL‐6 and PGE 2 levels, increased lung wet/dry weight ratio and bronchoalveolar protein concentration, and an impaired pulmonary gas exchange. Indomethacin treatment normalized plasma PGE 2 levels and pulmonary edema. Basal pulmonary permeability in isolated lungs was higher in OZ than LZ, with a further increase in permeability following treatment with PGE 2 . Conclusions: These results suggest that pulmonary edema in OZ following orthopedic trauma is due to an elevated PGE 2 and resultant increases in pulmonary permeability.