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A New Method to Measure Peripheral Retinal Vascular Caliber over an Extended Area
Author(s) -
CHEUNG CAROL YIMLUI,
HSU WYNNE,
LEE MONG LI,
WANG JIE JIN,
MITCHELL PAUL,
LAU QIANGFENG PETER,
HAMZAH HASLINA,
HO MAISIE,
WONG TIEN YIN
Publication year - 2010
Publication title -
microcirculation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.793
H-Index - 83
eISSN - 1549-8719
pISSN - 1073-9688
DOI - 10.1111/j.1549-8719.2010.00048.x
Subject(s) - caliber , retinal , intraclass correlation , fundus (uterus) , central retinal artery , ophthalmology , medicine , retinal artery , anatomy , central retinal vein , linear regression , mathematics , statistics , reproducibility , materials science , metallurgy
Please cite this paper as: Cheung, Hsu, Lee, Wang, Mitchell, Lau, Hamzah, Ho and Wong (2010). A New Method to Measure Peripheral Retinal Vascular Caliber over an Extended Area. Microcirculation 17(7) , 495–503. Abstract Objective: To describe a new computer‐assisted method to measure retinal vascular caliber over an extended area of the fundus. Methods: Retinal photographs taken from participants of the Singapore Malay Eye Study ( n = 3280) were used for this study. Retinal vascular caliber was measured and summarized as central retinal artery equivalent (CRAE) and central retinal vein equivalent (CRVE) using a new semi‐automated computer‐based program. Measurements were made at the Standard zone (from 0.5 to 1.0 disk diameter) and an Extended zone (from 0.5 to 2.0 disk diameter). Results: Reliability of retinal vascular caliber measurement was high for the new Extended zone (intraclass correlation coefficients >0.90). Associations of CRAE with blood pressure were identical between the Extended and Standard zones (linear regression coefficient −2.53 vs. −2.61, z ‐test between the two measurements, p = 0.394). Associations of CRAE and CRVE with other cardiovascular risk factors were similar between measurements in the two zones. The R 2 of regression models for the Extended zone was slightly higher than that for the Standard zone for both CRAE ( R 2 , 0.324 vs. 0.288) and CRVE ( R 2 , 0.325 vs. 0.265). Conclusions: The new measures from Extended zone are comparable with the previous measures, and also more representative of retinal vascular caliber.