Premium
Vanilloid and Melastatin Transient Receptor Potential Channels in Vascular Smooth Muscle
Author(s) -
Earley Scott
Publication year - 2010
Publication title -
microcirculation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.793
H-Index - 83
eISSN - 1549-8719
pISSN - 1073-9688
DOI - 10.1111/j.1549-8719.2010.00026.x
Subject(s) - transient receptor potential channel , transient (computer programming) , chemistry , vascular smooth muscle , biophysics , smooth muscle , receptor , microbiology and biotechnology , medicine , endocrinology , biology , computer science , biochemistry , operating system
Microcirculation (2010) 17 , 237–249. doi: 10.1111/j.1549‐8719.2010.00026.x Abstract The mammalian transient receptor potential (TRP) superfamily consists of six subfamilies that are defined by structural homology: TRPC ( c onventional or c anonical), TRPV ( v anilloid), TRPM ( m elastatin), TRPA ( a nkyrin), TRPP ( p olycystin), and TRPML ( m uco l iptin). This review focuses on channels belonging to the vanilloid (V) and melastatin (M) TRP subfamilies. The TRPV subfamily consists of six members (TRPV1‐6) and the TRPM subfamily has eight (TRPM1‐8). The basic biophysical properties of these channels are briefly described. All of these channels except TRPV5, TRPV6, and TRPM1 are reportedly present in arterial smooth muscle from various segments of the vasculature. Studies demonstrating involvement of TRPV1, TRPV2, TRPV4, TRPM4, TRPM7, and TRPM8 in regulation of arterial smooth muscle function are reviewed. The functions of TRPV3, TRPM2, TRPM3, and TRPM6 channels in arterial myocytes have not been reported.