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Pancreatic Enzymes and Microvascular Cell Activation in Multiorgan Failure
Author(s) -
SCHMIDSCHÖNBEIN GEERT W.,
HUGLI TONY E.,
KISTLER ERIK B.,
SOFIANOS ANASTASIA,
MITSUOKA HIROSHI
Publication year - 2001
Publication title -
microcirculation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.793
H-Index - 83
eISSN - 1549-8719
pISSN - 1073-9688
DOI - 10.1111/j.1549-8719.2001.tb00153.x
Subject(s) - microcirculation , multiorgan failure , pancreatic enzymes , shock (circulatory) , enzyme , microbiology and biotechnology , medicine , biology , pancreas , biochemistry
Cell activation in the microcirculation leads to an inflammatory cascade and is accompanied by many cardiovascular complications. There is a need to identify the trigger mechanisms that lead to the production of in vivo activating factors. We review here mechanisms for cell activation in the microcirculation and specifically the production of humoral cell activators in physiological shock. The elevated levels of activating factors in plasma could be traced to the action of pancreatic enzymes in the ischemic intestine. New interventions against the production of the activators are proposed. The evidence suggests that pancreatic enzymes in the ischemic intestine may attack several tissue components and generate cellular activators that are associated with multiorgan dysfunction in physiological shock.