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Therapeutic Management of Chronic Venous Insufficiency: Microcirculation as a Target
Author(s) -
BERGAN JOHN J.,
SCHMIDSCHÖNBEIN GEERT W.
Publication year - 2000
Publication title -
microcirculation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.793
H-Index - 83
eISSN - 1549-8719
pISSN - 1073-9688
DOI - 10.1111/j.1549-8719.2000.tb00147.x
Subject(s) - chronic venous insufficiency , medicine , venous hypertension , microcirculation , intensive care medicine , cardiology , weakness , venous return curve , surgery , hemodynamics
Chronic venous insufficiency, in its most severe manifestations as well as in its mild form, is linked to venous valve failure, weakness of the venous wall, and leukocyte‐endothelial interactions all of which lead to cutaneous and subcutaneous tissue changes. These in turn are related to venous hypertension‐induced leukocyte activation, which may provide a target for pharmacotherapeutic intervention. Currently, surgical attack is focused on correction of the sources of venous hypertension, but it is felt that this provides a crude method that hopefully will be replaced by more precise pharmacological interventions.