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Angiogenesis in P‐ and E‐Selectin‐Deficient Mice
Author(s) -
HARTWELL D.W.,
BUTTERFIELD C.E.,
FRENETTE P.S.,
KENYON B.M.,
HYNES R.O.,
FOLKMAN J.,
WAGNER DENISA D.
Publication year - 1998
Publication title -
microcirculation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.793
H-Index - 83
eISSN - 1549-8719
pISSN - 1073-9688
DOI - 10.1111/j.1549-8719.1998.tb00066.x
Subject(s) - angiogenesis , selectin , cytokine , fibroblast growth factor , tumor necrosis factor alpha , e selectin , immunology , in vivo , microbiology and biotechnology , chemistry , cancer research , medicine , inflammation , biology , adhesion , cell adhesion , receptor , organic chemistry
ABSTRACT Objectives : Several observations reported earlier indicated that the selectins, in particular E‐selectin, might be involved in angiogenesis; however, mice deficient in the endothelial selectins develop normally. To clarify the role of endothelial selectins in angiogenesis, we have studied experimentally induced angiogenesis in selectin‐deficient mice. Methods : Hydron pellets containing either basic fibroblast growth factor or the inflammatory cytokine tumor necrosis factor α were implanted into the corneas of wild‐type and P‐ and/or E‐selectin‐deficient mice. Results : The lengths and circumferential range of the newly formed blood vessels in the corneas of the endothelial selectin‐deficient mice were similar to those of wild‐type mice. Conclusion : The endothelial selectins are not essential in experimentally induced angiogenesis in vivo .