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Piperacillin‐induced thrombocytopenia reversed by high‐flux hemodialysis in an uremic patient
Author(s) -
Lin ShangYi,
Huang JiunChi,
Shen MeiChiou,
Chuang ShuHui,
Lee MeiHsuan,
Chen HuangChi
Publication year - 2012
Publication title -
hemodialysis international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.658
H-Index - 47
eISSN - 1542-4758
pISSN - 1492-7535
DOI - 10.1111/j.1542-4758.2012.00745.x
Subject(s) - medicine , piperacillin/tazobactam , hemodialysis , piperacillin , tazobactam , platelet , intensive care medicine , surgery , genetics , bacteria , pseudomonas aeruginosa , biology
Drug‐induced thrombocytopenia in an infected patient often is overlooked. We present a 74‐year‐old uremic female with continuous renal replacement therapy developed severe thrombocytopenia during the treatment course of piperacillin/tazobactam. Platelet counts recovered rapidly after discontinuing piperacillin/tazobactam and receiving high‐flux hemodialysis. The G eorge criteria indicates piperacillin/tazobactam as the probable cause of thrombocytopenia in this patient. Immediate withdrawal of the causative drug is important for drug‐induced thrombocytopenia. Prompt high‐flux hemodialysis may be an adjunctive management for uremic patients.