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Changes in circulating biomarkers during a single hemodialysis session
Author(s) -
Yamamoto Tae,
Nascimento Marcelo M.,
Hayashi Shirley Y.,
Qureshi Abdul Rashid,
Waniewski Jacek,
Brodin Lars Åke,
Anderstam Björn,
Lind Britta,
Riella Miguel C.,
Seeberger Astrid,
Lindholm Bengt
Publication year - 2013
Publication title -
hemodialysis international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.658
H-Index - 47
eISSN - 1542-4758
pISSN - 1492-7535
DOI - 10.1111/j.1542-4758.2012.00720.x
Subject(s) - medicine , hemodialysis , fibroblast growth factor 23 , osteoprotegerin , inflammation , hemoconcentration , endocrinology , oxidative stress , biomarker , hyperphosphatemia , hematocrit , parathyroid hormone , calcium , biochemistry , chemistry , receptor , activator (genetics)
The hemodialysis ( HD ) procedure induces an inflammatory response potentially contributing to cardiovascular disease. Here we investigated the acute impact of HD on circulating biomarkers. Circulating biomarkers (small solutes, middle molecular‐sized peptides, and proteins) related to inflammation, oxidative stress, and vascular calcification ( VC ) were measured before and after a single session of HD in 45 clinically stable patients. Concentrations were corrected for ultrafiltration‐induced hemoconcentration. Among vascular calcification‐related biomarkers, osteoprotegerin and fetuin‐ A remained unchanged while fibroblast growth factor‐23 ( FGF 23) decreased by −19%. Changes of FGF 23 and changes of phosphate correlated (ρ = 0.61, P < 0.001). While C ‐reactive protein did not change, interleukin‐6 ( IL ‐6) increased by 14% and pentraxin 3 ( PTX 3) increased by 45%. IL ‐6 and PTX 3 appear to be valid biomarkers of the intradialytic inflammatory response. VC ‐related markers were in general not affected by the single HD session; however, the observed correlation between acute changes of FGF ‐23 and phosphate during HD warrants further studies.