Premium
Acquired factor VIII inhibitor in a nonhemophilia patient on hemodialysis: challenges in management
Author(s) -
PHADKE Gautam,
GUPTA Diptesh,
BOTDORF Joshua,
MISRA Madhukar
Publication year - 2010
Publication title -
hemodialysis international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.658
H-Index - 47
eISSN - 1542-4758
pISSN - 1492-7535
DOI - 10.1111/j.1542-4758.2010.00489.x
Subject(s) - medicine , hemodialysis , intensive care medicine , risk factor , systemic lupus erythematosus , disease
It is well known that the uremic milieu predisposes patients to an increased risk of bleeding. We report a case of a patient on hemodialysis who developed recurrent unexplained bleeding episodes. His renal failure was secondary to systemic lupus erythematosus. Further investigations revealed that his bleeding was secondary to the development of acquired inhibitors to factor VIII: C following a flare up of his systemic lupus erythematosus. Management issues related to recurrent bleeding in this situation are discussed and reviewed.