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Renal dysfunction due to leukemic infiltration of kidneys in a case of chronic lymphocytic leukemia
Author(s) -
FERREIRA Ana Carina,
BRUM Sandra,
CARVALHO Dulce,
PATACA Isabel,
CARVALHO Fernanda,
SANTOS Maria Céu,
SANTOS João Ribeiro
Publication year - 2010
Publication title -
hemodialysis international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.658
H-Index - 47
eISSN - 1542-4758
pISSN - 1492-7535
DOI - 10.1111/j.1542-4758.2009.00395.x
Subject(s) - medicine , chronic lymphocytic leukemia , fludarabine , cyclophosphamide , prednisolone , infiltration (hvac) , hemodialysis , renal biopsy , leukemia , chlorambucil , pathology , leukostasis , biopsy , chemotherapy , physics , thermodynamics
Renal failure due to leukemic infiltration of kidney in chronic lymphocytic leukemia is an extremely rare condition. The authors report a case of a 59‐year‐old white female, with a past medical history of chronic lymphocytic leukemia (CLL) with 2 years of evolution without medical therapy, admitted with nonoliguric acute renal failure needing dialysis. Renal biopsy showed extensive small lymphocytes' infiltration in the cortical interstitium by CLL cells. Cyclophosphamide and prednisolone were started and 1 month later changed to fludarabine plus cyclophosphamide with improvement of renal function. Although renal failure due to leukemic infiltration has been described in many cases of acute leukemia, only 11 cases of renal failure due to CLL cells' infiltration have been described in the literature. Renal histology is an extremely important tool to confirm diagnosis.