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Toward better renoprotection: Lessons from angiotensin receptor blockers
Author(s) -
MIYATA Toshio,
TAKIZAWA Shunya
Publication year - 2007
Publication title -
hemodialysis international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.658
H-Index - 47
eISSN - 1542-4758
pISSN - 1492-7535
DOI - 10.1111/j.1542-4758.2007.00164.x
Subject(s) - medicine , diabetic nephropathy , angiotensin receptor blockers , kidney disease , renin–angiotensin system , intensive care medicine , blood pressure , nephropathy , pharmacology , hemodialysis , kidney , endocrinology , diabetes mellitus
The rising tide of chronic kidney disease (CKD), especially diabetic nephropathy, has become a worldwide catastrophe. However, therapeutic options to prevent or retard the progression of CKD still remain very limited. The understanding of its molecular mechanisms and the delineation of tools able to modify them are thus of critical importance. The discovery that some antihypertensive agents inhibiting the renin‐angiotensin system, such as angiotensin II type 1 receptor blockers, protect the kidney opens new therapeutic perspectives. In this article, we focus on their renoprotective actions beyond blood pressure lowering.