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HCO 3 increment in arterial line can reveal significant vascular access recirculation in high‐flux hemodialysis: A preliminary report
Author(s) -
SOMBOLOS Kostas I.,
CHRISTIDOU Fotini N.,
BAMICHAS Gerasimos I.,
GIONANLIS Lazaros D.,
KARAGIANNI Anna C.,
ANAGNOSTOPOULOS Theodoros C.,
NATSE Taïsir A.
Publication year - 2006
Publication title -
hemodialysis international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.658
H-Index - 47
eISSN - 1542-4758
pISSN - 1492-7535
DOI - 10.1111/j.1542-4758.2006.01180.x
Subject(s) - hemodialysis , arterial line , medicine , arterial blood , anesthesia , cardiology
We report a new and simple way that can reveal the presence of vascular access recirculation (VAR) in patients undergoing hemodialysis (HD). Acid‐base and blood gas parameters (pH, pO 2 , pCO 2 , and HCO 3 ) were measured in blood samples drawn from an arterial fistula needle before the initiation of HD and from arterial and venous lines simultaneously 5 min later, in 31 patients (group A). Vascular access recirculation was measured using the glucose infusion test (GIT) immediately after the withdrawal of the 5‐min samples. The same study was repeated in 30 patients in whom HD lines were reversed (group B). A comparison with baseline (predialysis) values of an analysis of the arterial line in group A at 5 min revealed that pCO 2 increased by 1.14±2.5 mmHg and HCO 3 by 0.6±0.6 mM/L (p<0.02 and p<0.00001, respectively). The corresponding pO 2 and pH values did not show significant differences. Glucose infusion test at 5 min (GITa) was −0.058±0.03%. A comparison with baseline (predialysis) values of an analysis of the arterial line in group B at 5 min revealed that pCO 2 increased by 7.7±3.5 mmHg and HCO 3 by 2.9±1.0 mM/L (p<0.1 in each case). The pH level was significantly lower in comparison with baseline values (p<0.00001), while pO 2 did not show a significant difference. Glucose infusion test at 5 min (GITb) was 12.0±6.1% (p<0.1 in comparison with GITa values). Clinically significant VAR was defined as HCO 3 increment >1.8 mM/L, based on the receiver‐operating characteristics curve, which showed a threshold value of HCO 3 increment >1.8 mmol/L as a predictor of GIT recirculation. Five minutes after the initiation of high‐flux HD with a 0 ultrafiltration rate, there is a small increment in arterial HCO 3 values relative to predialysis values. Clinically significant VAR is present when this increment is higher than 1.8 mM/L.