Subtraction Magnetocardiogram for Detecting Coronary Heart Disease

Background: A large‐scale magnetocardiogram (MCG) database was produced, and standard MCG waveforms of healthy patients were calculated by using this database. It was clarified that the standard MCG waveforms are formed with the same shape and current distribution in healthy patients. A new subtraction method for detecting abnormal ST‐T waveforms in coronary heart disease (CHD) patients by using the standard MCG waveform was developed. Methods: We used MCGs of 56 CHD patients (63 ± 3 years old) and 101 age‐matched normal control patients (65 ± 5 years old). To construct a subtracted ST‐T waveform, we used standard MCG waveforms produced from 464 normal MCGs (male: 268, female: 196). The standard MCG waveforms were subtracted from each subject's measured MCGs, which were shortened or lengthened and normalized to adjust to the data length and magnitude of the standard waveform. We evaluated the maximum amplitude and maximum current‐arrow magnitude of the subtracted ST‐T waveform. Results: The maximum magnetic field, maximum magnitude of current arrows, and maximum magnitude of total current vector increased according to the number of coronary artery lesions. The sensitivity and specificity of detecting CHD and normal control patients were 74.6% and 84.1%, respectively. Conclusions: The subtraction MCG method can be used to detect CHD with high accuracy, namely, sensitivity of 74.6% and specificity of 84.1% (in the case of maximum amplitude of total current vector). Furthermore, the subtraction MCG magnitude and its current distribution can reflect the expanse of the ischemic lesion area and the progress from ischemia to myocardial infarction. Ann Noninvasive Electrocardiol 2010;15(4):360‐368