Open AccessIs Rhythm‐Control Superior to Rate‐Control in Patients with Atrial Fibrillation and Diastolic Heart Failure?
Author(s) -
Kong Melissa H.,
Shaw Linda K.,
O’Connor Christopher,
Califf Robert M.,
Blazing Michael A.,
AlKhatib Sana M.
Publication year - 2010
Publication title -
annals of noninvasive electrocardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.494
H-Index - 48
eISSN - 1542-474X
pISSN - 1082-720X
DOI - 10.1111/j.1542-474x.2010.00365.x
Subject(s) - medicine , atrial fibrillation , heart failure , cardiology , hazard ratio , ejection fraction , rhythm , heart rate , observational study , heart failure with preserved ejection fraction , diastolic heart failure , randomized controlled trial , proportional hazards model , diastole , blood pressure , confidence interval
Background: Although no clinical trial data exist on the optimal management of atrial fibrillation (AF) in patients with diastolic heart failure, it has been hypothesized that rhythm‐control is more advantageous than rate‐control due to the dependence of these patients’ left ventricular filling on atrial contraction. We aimed to determine whether patients with AF and heart failure with preserved ejection fraction (EF) survive longer with rhythm versus rate‐control strategy. Methods: The Duke Cardiovascular Disease Database was queried to identify patients with EF > 50%, heart failure symptoms and AF between January 1,1995 and June 30, 2005. We compared baseline characteristics and survival of patients managed with rate‐ versus rhythm‐control strategies. Using a 60‐day landmark view, Kaplan‐Meier curves were generated and results were adjusted for baseline differences using Cox proportional hazards modeling. Results: Three hundred eighty‐two patients met the inclusion criteria (285 treated with rate‐control and 97 treated with rhythm‐control). The 1‐, 3‐, and 5‐year survival rates were 93.2%, 69.3%, and 56.8%, respectively in rate‐controlled patients and 94.8%, 78.0%, and 59.9%, respectively in rhythm‐controlled patients (P > 0.10). After adjustments for baseline differences, no significant difference in mortality was detected (hazard ratio for rhythm‐control vs rate‐control = 0.696, 95% CI 0.453–1.07, P = 0.098). Conclusions: Based on our observational data, rhythm‐control seems to offer no survival advantage over rate‐control in patients with heart failure and preserved EF. Randomized clinical trials are needed to verify these findings and examine the effect of each strategy on stroke risk, heart failure decompensation, and quality of life. Ann Noninvasive Electrocardiol 2010;15(3):209–217